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カタログ番号	製品名	別名	ターゲット
T8873	Bractoppin		Others , DNA/RNA Synthesis
	Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activi...		Others , DNA/RNA Synthesis
T38272	Thiacloprid		AChR , Parasite
	Thiacloprid is a neonicotinoid insecticide that acts as a selective agonist at insect nicotinic acetylcholine receptors (nAChRs) with IC50values of 2.7 and 860 nM forDrosophilanAChRs and M10 mouse fibroblast cells expres...		AChR , Parasite
T3103	L67	DNA Ligase Inhibitor	DNA , DNA/RNA Synthesis
	L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).		DNA , DNA/RNA Synthesis
T1767	BMH-21	BMH21	DNA/RNA Synthesis
	BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.		DNA/RNA Synthesis
T1564	Cisplatin	cis-Diaminodichloroplatinum,CDDP	DNA Alkylator/Crosslinker , Ferroptosis , DNA/RNA Synthesis , Autophagy
	Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also activates iron death and induces autophagy.
T9271	RAD51-IN-1		DNA/RNA Synthesis
	Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.		DNA/RNA Synthesis
T4470	Pyridostatin TFA		DNA/RNA Synthesis
	Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.		DNA/RNA Synthesis
T27029	Cjoc42	cjoc 42,cjoc-42
	Cjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. cjoc42 prevents the decrease in p53 protein levels normally associated w...
T9849	HQ461		CDK , Molecular Glues
	HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.		CDK , Molecular Glues
T9497	Niraparib tosylate monohyrate		PARP
	Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting...		PARP
T5399	GeA-69		PARP
	GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).		PARP
T14141	AGI-24512		Others , Methionine Adenosyltransferase (MAT)
	AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in vitro.		Others , Methionine Adenosyltransferase (MAT)
T8869	B355252		Others
	B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth.		Others
T6303	CCT128930		Akt , PKA , S6 Kinase , Autophagy
	CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase.		Akt , PKA , S6 Kinase , Autophagy
T8492	BO-264		Apoptosis , FGFR
	BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).		Apoptosis , FGFR
T1899	Pyridostatin	RR82,Pyridostatin Trifluoroacetate Salt	DNA/RNA Synthesis
	Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres.		DNA/RNA Synthesis
T1640	Ciprofloxacin	Ciproxan,Ciprobay,Bay o 9867,Bay-09867	Topoisomerase , Antibacterial , Antibiotic
	Ciprofloxacin (Bay-09867), a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-positive bacteria.		Topoisomerase , Antibacterial , Antibiotic
T9024	OUL35	NSC39047	Others , PARP
	OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.		Others , PARP
T3231	Niraparib	MK-4827	Apoptosis , Others , PARP
	Niraparib (MK-4827) is a PARP inhibitor that selectively inhibits PARP1 and PARP2 (IC50=3.8/2.1 nM). Niraparib has antitumor activity, inhibits DNA damage repair, and induces apoptosis.		Apoptosis , Others , PARP
T7318	Elimusertib	BAY-1895344	ATM/ATR
	Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target...		ATM/ATR
T0250	Ciprofloxacin monohydrochloride	Bay-09867 (hydrochloride),Ciprofloxacin HCl,Ciprofloxacin hydrochloride	DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
	Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.		DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
T40192	DGTP	2'-Deoxyguanosine-5'-triphosphate	Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.		Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
T3289	Amifostine	Ethyol,WR2721,Gammaphos	Others , HIF/HIF Prolyl-Hydroxylase
	Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.		Others , HIF/HIF Prolyl-Hydroxylase
T5994	KPT-6566		Others
	KPT-6566 is a novel selective covalent pin1 inhibitor, KPT-6566 shows an IC50 of 640 nM and a Ki of 625.2 nM for PIN1 PPIase domain,and has anti-cancer activity.		Others
T6381	Amifostine trihydrate	Ethyol trihydrate,WR2721,Amifostine	Others , HIF/HIF Prolyl-Hydroxylase
	Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.		Others , HIF/HIF Prolyl-Hydroxylase
T6611	NSC697923	2-[(4-methylphenyl)sulfonyl]-5-nitrofuran	E1/E2/E3 Enzyme
	NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct me...		E1/E2/E3 Enzyme
T6303L	CCT128930 hydrochloride	CCT128930 hydrochloride(885499-61-6 Free base)	Apoptosis , Akt , PKA , mTOR , Autophagy
	CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28...		Apoptosis , Akt , PKA , mTOR , Autophagy
T3353	Niraparib hydrochloride	MK-4827 hydrochloride,MK-4827 (hydrochloride)	Apoptosis , Others , PARP
	Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochloride inhibits PARP activity, enhancing the accumulation of...		Apoptosis , Others , PARP
T6892	Niraparib tosylate	MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate	Apoptosis , PARP
	Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.		Apoptosis , PARP
T0095	Bendamustine hydrochloride	SDX-105,SDX-105 (Cytostasane) HCl,Bendamustine HCl,EP-3101	Apoptosis , DNA Alkylator/Crosslinker , DNA/RNA Synthesis
	Bendamustine hydrochloride (EP-3101) (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
T2410	Nedaplatin	NSC 375101D	DNA/RNA Synthesis
	Nedaplatin (NSC-375101D) is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand...		DNA/RNA Synthesis
T23974	DDRI-18	DDRI18,DDRI 18	DNA/RNA Synthesis
	DDRI-18 is a novel small molecule inhibitor that regulates the DNA damage response with sensitizing and anticancer activities, inhibits non-homologous end-joining (NHEJ) DNA repair and enhances the cytotoxicity of antica...		DNA/RNA Synthesis
T12682	Emzadirib	CYT-0851,RAD51-IN-2	DNA/RNA Synthesis
	Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.		DNA/RNA Synthesis
T0164	Oxaliplatin	L-OHP	DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
	Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autop...
T6610	XI-006	NSC 207895	Mdm2 , p53
	XI-006 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.		Mdm2 , p53
T2077	Adavosertib	AZD1775,MK-1775,Adavosertib (MK-1775)	Wee1
	Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.		Wee1
T31425	Dibenz[a,h]anthracene	CCRIS 208,NSC 22433,AI3-18996,DB(a,h)A	DNA
	Dibenz[a,h]anthracene (CCRIS 208) has induced DNA damage and gene mutations in bacteria and gene mutations and transformation in several types of mammalian cell cultures.		DNA
T10406	Tuvusertib	M1774,ATR inhibitor 1	Apoptosis , ATM/ATR , Others , Chk
	Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks...		Apoptosis , ATM/ATR , Others , Chk
T14125	Adarotene	ST1926	Apoptosis
	Adarotene (ST1926) is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor cells.		Apoptosis
T19151	5-Chloro-2'-deoxyuridine	5-Chlorodeoxyuridine,CldU	Others
	5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors.		Others
T4575	Chromium picolinate		DNA , p38 MAPK
	Chromium picolinate causes DNA damage and mutation. It is an activator of p38.		DNA , p38 MAPK
T38410	Phosphoramide mustard		DNA Alkylation , Drug Metabolite
	Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.		DNA Alkylation , Drug Metabolite
T70873	M3541		Apoptosis , ATM/ATR
	M3541 is a selectively potent and orally active ATM inhibitor with potential antitumor activity.M-3541 inhibits ATM kinase activity and ATM-mediated signaling by binding to ATM.M3541 prevents activation of DNA damage che...		Apoptosis , ATM/ATR
T125462	Gnetifolin K	GnetifolinK
	Gnetifolin K (GnetifolinK) is a novel stilbene diglucoside from Gnetum parvifolium with potential neuroprotective activity for the study of DNA damage.
T9463	6-HYDROXYLAMINOURACIL		Others
	6-HYDROXYLAMINOURACIL is a derivative of uracil, which induces DNA damage and apoptosis in tumor cells and inhibits tumor cell growth in vitro.		Others
T23284	Ryuvidine		Histone Demethylase , Histone Methyltransferase , CDK
	Ryuvidine is a dual inhibitor of KDM5A and SETD8, an inducer of the DNA damage response with potential anticancer activity, inhibition of H4K20 methylation, and inhibition of CDK4, and can be used to study breast cancer ...		Histone Demethylase , Histone Methyltransferase , CDK
T10487	BCL6-IN-3		BCL , Others , DNA
	BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity.		BCL , Others , DNA
T39849	Propargite		Parasite
	Propargite is a pesticide used to kill mites. Propargite induces β-cell necrosis preceded by DNA damage. Propargite induces MIN6 cell death with an IC 50 of 1 μM [1] .		Parasite
TP1430	DTP3 TFA (1809784-29-9 free base)	DTP3 TFA	Others
	DTP3 TFA (1809784-29-9 free base) (DTP3 TFA) is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor.		Others
T2069L	TH287 hydrochloride		DNA/RNA Synthesis , MTH1
	TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.		DNA/RNA Synthesis , MTH1

Compounds

Bractoppin

T8873

Synonym:

Target: Others, DNA/RNA Synthesis

Thiacloprid

T38272

Synonym:

Target: AChR, Parasite

L67

T3103

Synonym: DNA Ligase Inhibitor

Target: DNA, DNA/RNA Synthesis

BMH-21

T1767

Synonym: BMH21

Target: DNA/RNA Synthesis

Cisplatin

T1564

Synonym: cis-Diaminodichloroplatinum,CDDP

Target: DNA Alkylator/Crosslinker, Ferroptosis, DNA/RNA Synthesis, Autophagy

RAD51-IN-1

T9271

Synonym:

Target: DNA/RNA Synthesis

Pyridostatin TFA

T4470

Synonym:

Target: DNA/RNA Synthesis

cjoc42

T27029

Synonym: cjoc 42,cjoc-42

Target: CDK, Molecular Glues

Niraparib tosylate monohyrate

Target: Others, Methionine Adenosyltransferase (MAT)

Target: Akt, PKA, S6 Kinase, Autophagy

BO-264

T8492

Synonym:

Target: Apoptosis, FGFR

Pyridostatin

T1899

Synonym: RR82,Pyridostatin Trifluoroacetate Salt

Target: DNA/RNA Synthesis

Ciprofloxacin

T1640

Synonym: Ciproxan,Ciprobay,Bay o 9867,Bay-09867

Target: Topoisomerase, Antibacterial, Antibiotic

Target: Apoptosis, Others, PARP

Ciprofloxacin monohydrochloride

T0250

Synonym: Bay-09867 (hydrochloride),Ciprofloxacin HCl,Ciprofloxacin hydrochloride

Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic

dGTP

T40192

Synonym: 2'-Deoxyguanosine-5'-triphosphate

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Amifostine

T3289

Synonym: Ethyol,WR2721,Gammaphos

Target: Others, HIF/HIF Prolyl-Hydroxylase

Amifostine trihydrate

T6381

Synonym: Ethyol trihydrate,WR2721,Amifostine

Target: Others, HIF/HIF Prolyl-Hydroxylase

NSC697923

T6611

Synonym: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran

Target: E1/E2/E3 Enzyme

CCT128930 hydrochloride

T6303L

Synonym: CCT128930 hydrochloride(885499-61-6 Free base)

Target: Apoptosis, Akt, PKA, mTOR, Autophagy

Niraparib hydrochloride

T3353

Synonym: MK-4827 hydrochloride,MK-4827 (hydrochloride)

Target: Apoptosis, Others, PARP

Niraparib tosylate

T6892

Synonym: MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate

Target: Apoptosis, PARP

Bendamustine hydrochloride

T0095

Synonym: SDX-105,SDX-105 (Cytostasane) HCl,Bendamustine HCl,EP-3101

Target: Apoptosis, DNA Alkylator/Crosslinker, DNA/RNA Synthesis

Nedaplatin

T2410

Synonym: NSC 375101D

Target: DNA/RNA Synthesis

DDRI-18

T23974

Synonym: DDRI18,DDRI 18

Target: DNA/RNA Synthesis

Emzadirib

T12682

Synonym: CYT-0851,RAD51-IN-2

Target: DNA/RNA Synthesis

Oxaliplatin

T0164

Synonym: L-OHP

Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy

Synonym: AZD1775,MK-1775,Adavosertib (MK-1775)

Target: Wee1

Dibenz[a,h]anthracene

T31425

Synonym: CCRIS 208,NSC 22433,AI3-18996,DB(a,h)A

Target: DNA

Tuvusertib

T10406

Synonym: M1774,ATR inhibitor 1

Target: Apoptosis, ATM/ATR, Others, Chk

5-Chloro-2'-deoxyuridine

T19151

Synonym: 5-Chlorodeoxyuridine,CldU

Target: DNA, p38 MAPK

Phosphoramide mustard

T38410

Synonym:

Target: DNA Alkylation, Drug Metabolite

M3541

T70873

Synonym:

Target: Apoptosis, ATM/ATR

6-HYDROXYLAMINOURACIL

Target: Histone Demethylase, Histone Methyltransferase, CDK

BCL6-IN-3

T10487

Synonym:

Target: BCL, Others, DNA

DTP3 TFA (1809784-29-9 free base)

Target: DNA/RNA Synthesis, MTH1

カタログ番号	製品名	別名	ターゲット
T21498	Phleomycin		DNA/RNA Synthesis , Antibacterial , Antibiotic
	Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage. It is similar to Bleomycin which binds and intercalates DNA to damage the integrity of the double helix.		DNA/RNA Synthesis , Antibacterial , Antibiotic
T0956	Avermectin B1	Avermectin B1a-Avermectin B1b mixt.,Abamectin	Antibiotic , Parasite , Autophagy
	Avermectin B1 is served as anthelmintic and insecticide.		Antibiotic , Parasite , Autophagy
T3673	Mollugin	Rubimaillin	HER , JAK
	Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upr...		HER , JAK
T8130	Ciprofloxacin hydrochloride monohydrate	Oftacilox,Ciprofloxacin hydrochloride hydrate,Bay-09867 hydrochloride monohydrate,Ceprimax,Ciloxan	Antibacterial , Antibiotic
	Ciprofloxacin hydrochloride monohydrate (Bay-09867 hydrochloride monohydrate) is a fluoroquinolone antibiotic,is an antibiotic used to treat a number of bacterial infections		Antibacterial , Antibiotic
T2S2003	Phlorizin dihydrate	Phloridzin dihydrate	Others
	1. Phlorizin dihydrate (Phloridzin dihydrate) can significantly inhibit oxidative DNA damage.		Others
T40370	2′-Deoxyadenosine 5′-monophosphate disodium		Endogenous Metabolite
	2′-Deoxyadenosine 5′-monophosphate disodium, a nucleic acid AMP derivative, is a deoxyribonucleotide present in DNA. It is employed for researching adenosine-based interactions within DNA synthesis and damage analysis.		Endogenous Metabolite
T19165	8-Hydroxyguanine	8 Hydroxyguanine,7,8-dihydro-8-oxoguanine,2-Amino-6,8-dihydroxypurine	Endogenous Metabolite
	8-Hydroxyguanine (8 Hydroxyguanine) is the major premutagenic damage produced by reactive oxygen species. It causes G-T and A-C substitutions.8-Hydroxyguanine is a biomarker for RNA oxidation and oxidative DNA damage.8-H...		Endogenous Metabolite
TN1698	Glucotropaeolin potassium	Glucotropaeolin,Benzylglucosinolate potassium,Glucotropaeolin Potassium Salt	Others
	Glucotropaeolin potassium (Benzylglucosinolate potassium) is found in cruciferous vegetables and moderately decrease spontaneous DNA damage in animals.		Others
T40834	5-Hydroxymethyl-2'-deoxycytidine	5hmdC	PARP
	5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA, causing DNA damage reactions, chromosomal aberrations, replication fork damage, and loss of cell viability.5-Hydroxy...		PARP
T4715	2'-Deoxyguanosine monohydrate	Guanine-2'-deoxyriboside	Others , Endogenous Metabolite
	2'-Deoxyguanosine monohydrate (Guanine-2'-deoxyriboside) is a nucleoside consisting of the base guanine and the sugar deoxyribose. It is like guanosine, but with one oxygen atom removed. It is a nucleoside component of D...		Others , Endogenous Metabolite
TN1043	Keracyanin chloride	Cyanidin-3-O-rutinoside chloride,Cyanidin 3-rutinoside chloride,Cyanidin 3-O-rutinoside chloride	COX
	Keracyanin chloride (Cyanidin 3-rutinoside chloride), an anthocyanin compound, exhibits antioxidant properties. It effectively prevents the formation of malonaldehyde in oxidized calf thymus DNA, underlining its potentia...		COX
T77563	4-Ethylcatechol		DNA
	4-Ethylcatechol is present in red wine and can be extracted from Glechoma longituba (NaKai) Kupr.4-Ethylcatechol induces DNA damage in the presence of Cu(II).4-Ethylcatechol is a potent antiplatelet compound.		DNA
TN1362	Afzelin	Kaempferol-3-O-rhamnoside	PTEN , p38 MAPK , TNF , Mitochondrial Metabolism , Antibacterial , Prostaglandin Receptor , Autophagy
	Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced d...
T3008	Lawsone methyl ether	2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone	Apoptosis , Antibacterial , Antifungal
	Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induced apoptosis of A549 cells independent of cell cycle arrest, and is mediated by the JNK and p38 MAPK signaling pathways. Further analysis demonstrated that these s...		Apoptosis , Antibacterial , Antifungal
T5S0636	Citric acid	Citro,Citretten	Apoptosis , Others , Endogenous Metabolite , Antibacterial , Antibiotic
	1. Citric acid (Citro) (1-2 g/kg) can decrease brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. 2. Citric acid denture cleansers can reduce C. albicans biofilm accumulation and cell viabili...
TN1461	(-)-Butin	Butin	Akt , PI3K , Nrf2
	(-)-Butin (Butin) has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates oxidative stress by activating Nrf2-mediated Mn SO...		Akt , PI3K , Nrf2
T3785	11-oxo-mogroside V	11-oxo Mogroside V	Reactive Oxygen Species
	11-oxo-mogroside V (11-oxo Mogroside V) is a sweet tasting cucurbitane glycoside derivative of mogroside V. It has antioxidant effects against both O2- and OH- and prevents OH-induced DNA damage.		Reactive Oxygen Species
T1633	β-Carotene	Carotaben,Beta-Carotene,Provitamin A	Apoptosis , ROS , Endogenous Metabolite
	β-Carotene (Provitamin A) is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene...		Apoptosis , ROS , Endogenous Metabolite
T9279	Nerolidol acetate		Others
	Nerolidol acetate is a natural sesquiterpene with anti-cancer, anti-inflammatory, antibacterial and anti-insect activities. Nerolidol acetate can inhibit parasite activity and inhibit schistosomiasis, nematodes, malaria,...		Others
T8280	Deacetylasperulosidic Acid	Desacetyl asperulosidic acid	IL Receptor , Interleukin
	Deacetylasperulosidic Acid is a natural compound of Morinda citrifolia fruit. It has antioxidant activity by increasing superoxide dismutase activity. It also prevents 4-nitroquinoline 1-oxide (4NQO) induced DNA damage i...		IL Receptor , Interleukin
TN1393	(-)-Anonaine		Apoptosis , Antioxidant , Parasite , Antifungal
	(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces ...		Apoptosis , Antioxidant , Parasite , Antifungal
T2988	(-)-Epigallocatechin Gallate	Epigallocatechol Gallate,EGCG	Ferroptosis , Reactive Oxygen Species , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite , Autophagy
	(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG) blocks the activation of EGF receptors and HER-2 receptor...
T5255	5-Hydroxymethyluracil	5-(Hydroxymethyl)uracil,Hydroxymethyl Uracil,a-Hydroxythymine	Others , Endogenous Metabolite
	5-Hydroxymethyluracil (a-Hydroxythymine) is an oxidation damage product derived from thymine or 5-methylcytosine. 5-Hydroxymethyluracil is a product of thymine dioxygenase. Additional deamination products such as 5-hydro...		Others , Endogenous Metabolite
TN2211	Silybin B	Silibinin B	Apoptosis , Beta Amyloid , Bcr-Abl
	Silybin B (Silibinin B) is an effective inhibitor of raloxifene 4 '- and 6-glucosalylation, an effective anti-fibrinogenic and anti-oligomeric component of Silymarin, with free radical scavenging activity of 1, 1-dipheny...		Apoptosis , Beta Amyloid , Bcr-Abl
T4971	5'-DEOXYADENOSINE	5′-dAdo	Endogenous Metabolite
	5'-Deoxyadenosine (5′-dAdo) is an oxidized nucleoside found in the urine of normal subjects. Oxidized nucleosides represent excellent biomarkers for determining the extent of damage in genetic material, which has long be...		Endogenous Metabolite
T2915	Bardoxolone	RTA 401,CDDO	Others , Nrf2
	Bardoxolone (CDDO) is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM. By supp...		Others , Nrf2
T4918	DL-Glyceraldehyde	Glyceric aldehyde	Reductase
	DL-Glyceraldehyde (Glyceric aldehyde) is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficiently high levels, ...		Reductase
T6S2099	Geraniin		Antioxidant , TNF
	1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation ...		Antioxidant , TNF
T1311	4-aminobenzoic acid	PABA,Vitamin H1,Vitamin Bx,para-Aminobenzoic acid	Endogenous Metabolite
	4-aminobenzoic acid (para-Aminobenzoic acid) is an organic acid with UV absorption and antifibrotic properties. When exposed to light, 4-aminobenzoic acid absorbs UV light and emits excess energy via a photochemical reac...		Endogenous Metabolite
T4S0797	Berberine	Berberin,Umbellatine	Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic , Autophagy
	1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3....
T10018	1-Methyladenine		Others
	1-Methyladenine is a DNA alkylation product that undergoes damage reversal through oxidative demethylation for repair purposes.		Others
TN4173	Guajadial C		Topoisomerase
	Guajadial C acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. It shows cytotoxicity against five human cancer cell lines.		Topoisomerase
TN6608	Cyanidin-3-O-arabinoside chloride
	Cyanidin-3-O-arabinoside chloride has antioxidant activity. It reduces the peroxynitrite-induced suppression of mitochondrial respiration, DNA damage, PARS activation and vascular dysfunction in HUVECs.
TN5348	Guajadial F
	Guajadial F acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. Guajadial F shows cytotoxicity against five human cancer cell lines.
T38036	Lumisterol
	Lumisterol (9β,10α-Ergosterol), a steroid compound and the (9β,10α)-stereoisomer of Ergosterol, serves as a photoprotective agent shielding against UVB-induced DNA damage and exhibits anti-proliferative activities[1].
TN3724	Cryptomoscatone D2		p53
	Cryptomoscatone D2 is a highly efficacious inhibitor of the G(2) checkpoint, and G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage to enter mitosis.		p53
TN4151	Glyurallin A		Others
	Glyurallin A possesses an antigenotoxic effect against carcinogenic N-methyl-N-nitrosourea (MNU) for the first time, it is important to prevent DNA damage by N-nitrosamines for cancer chemoprevention.		Others
TN4172	Guajadial B		Topoisomerase
	Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines, it is the most effective having an IC50 value of 150 nM to...		Topoisomerase
TN1359	Aflatoxin G1		TNF , NF-κB
	Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce lung adenocarcinoma.		TNF , NF-κB
TN4041	Eupatoriopicrin		Others
	Eupatoriopicrin shows anti-trypanosomal activity and cytotoxicity against Trypanosoma brucei rhodesiense. Eupatoriopicrin-induced DNA damage may play a role in the observed cytotoxicity, it shows a weak sensitizing capac...		Others
TN3403	Djalonensone	Alternariol monomethyl ether	Immunology/Inflammation related
	Djalonensone (Alternariol monomethyl ether), an Alternaria toxin, is a strong mutagen in Escherichia coli strain ND-160. Alternariol monomethyl ether has genotoxic properties, it can cause oxidative DNA damage. It also p...		Immunology/Inflammation related
TN3721	Cryptofolione		Antifection
	Z-Cryptofolione and Cryptomoscatone D2 as highly efficacious inhibitors of the G(2) checkpoint, G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage to enter mitosis. Cryptofolione shows modera...		Antifection
TN3973	Epinodosin		Others
	Epinodosin induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner.Epinodosin has a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in Lac...		Others
T27711	Kahweol Eicosanate	J002075,J 002075,J-002075
	Kahweol Eicosanate is a semi-syntetic derivative of kahweol. Kahweol Eicosanate exhibits a wide variety of biological activities, including inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, ...
T79991	Condurango glycoside A
	Condurango glycoside A activates p53, induces ROS generation, up-regulates p53 expression, and triggers apoptosis as well as premature senescence associated with DNA damage in HeLa cells [1].
T75622	β-Apopicropodophyllin
	β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage, cell cycle arrest, and ER stress. This compound holds potentia...
TN4890	Rabdosin B		Others
	Rabdosin B shows cytotoxic activity against three human tumour HepG2, GLC-82 and HL-60 cell lines, it induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner. Rabdosin B at higher concentration...		Others
TN4084	Fumitremorgin B		Antifection
	Fumitremorgen B is a mycotoxin, it exhibits a certain degree of genotoxicity, it can cause DNA damage in human lymphocytes; it shows an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M ph...		Antifection
TN5264	Xanthoxyletin		TNF , NOS , ROS , COX , Antifection
	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS protein expression at 10 microM, it also can...		TNF , NOS , ROS , COX , Antifection
TN2257	Tanshinone IIB		BCL , Caspase , P-gp
	Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the el...		BCL , Caspase , P-gp
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天然物製品

Phleomycin

T21498

Synonym:

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

Avermectin B1

T0956

Synonym: Avermectin B1a-Avermectin B1b mixt.,Abamectin

Target: Antibiotic, Parasite, Autophagy

Ciprofloxacin hydrochloride monohydrate

T8130

Synonym: Oftacilox,Ciprofloxacin hydrochloride hydrate,Bay-09867 hydrochloride monohydrate,Ceprimax,Ciloxan

Target: Antibacterial, Antibiotic

Phlorizin dihydrate

T2S2003

Synonym: Phloridzin dihydrate

Target: Others

2′-Deoxyadenosine 5′-monophosphate disodium

T40370

Synonym:

Target: Endogenous Metabolite

8-Hydroxyguanine

T19165

Synonym: 8 Hydroxyguanine,7,8-dihydro-8-oxoguanine,2-Amino-6,8-dihydroxypurine

Target: Endogenous Metabolite

Glucotropaeolin potassium

TN1698

Synonym: Glucotropaeolin,Benzylglucosinolate potassium,Glucotropaeolin Potassium Salt

Target: Others

5-Hydroxymethyl-2'-deoxycytidine

T40834

Synonym: 5hmdC

Target: PARP

2'-Deoxyguanosine monohydrate

T4715

Synonym: Guanine-2'-deoxyriboside

Target: Others, Endogenous Metabolite

Keracyanin chloride

TN1043

Synonym: Cyanidin-3-O-rutinoside chloride,Cyanidin 3-rutinoside chloride,Cyanidin 3-O-rutinoside chloride

Synonym: Kaempferol-3-O-rhamnoside

Target: PTEN, p38 MAPK, TNF, Mitochondrial Metabolism, Antibacterial, Prostaglandin Receptor, Autophagy

Lawsone methyl ether

T3008

Synonym: 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone

Target: Apoptosis, Antibacterial, Antifungal

Citric acid

T5S0636

Synonym: Citro,Citretten

Target: Apoptosis, Others, Endogenous Metabolite, Antibacterial, Antibiotic

(-)-Butin

TN1461

Synonym: Butin

Target: Akt, PI3K, Nrf2

11-oxo-mogroside V

T3785

Synonym: 11-oxo Mogroside V

Target: Reactive Oxygen Species

β-Carotene

T1633

Synonym: Carotaben,Beta-Carotene,Provitamin A

Target: Apoptosis, ROS, Endogenous Metabolite

Deacetylasperulosidic Acid

T8280

Synonym: Desacetyl asperulosidic acid

Target: IL Receptor, Interleukin

(-)-Anonaine

TN1393

Synonym:

Target: Apoptosis, Antioxidant, Parasite, Antifungal

(-)-Epigallocatechin Gallate

T2988

Synonym: Epigallocatechol Gallate,EGCG

Target: Ferroptosis, Reactive Oxygen Species, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite, Autophagy

5-Hydroxymethyluracil

T5255

Synonym: 5-(Hydroxymethyl)uracil,Hydroxymethyl Uracil,a-Hydroxythymine

Target: Others, Endogenous Metabolite

Silybin B

TN2211

Synonym: Silibinin B

Target: Apoptosis, Beta Amyloid, Bcr-Abl

5'-DEOXYADENOSINE

T4971

Synonym: 5′-dAdo

Target: Endogenous Metabolite

Bardoxolone

T2915

Synonym: RTA 401,CDDO

Target: Others, Nrf2

DL-Glyceraldehyde

T4918

Synonym: Glyceric aldehyde

Target: Antioxidant, TNF

4-aminobenzoic acid

T1311

Synonym: PABA,Vitamin H1,Vitamin Bx,para-Aminobenzoic acid

Target: Endogenous Metabolite

Berberine

T4S0797

Synonym: Berberin,Umbellatine

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Target: Topoisomerase

Cyanidin-3-O-arabinoside chloride

Target: Topoisomerase

Synonym: Alternariol monomethyl ether

Target: Immunology/Inflammation related

Synonym: J002075,J 002075,J-002075

Target:

Condurango glycoside A

T79991

Synonym:

Target:

β-Apopicropodophyllin

Target: TNF, NOS, ROS, COX, Antifection

Tanshinone IIB

TN2257

Synonym:

Target: BCL, Caspase, P-gp

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-03601	PDRG1 Protein, Human, Recombinant (His)	Human	E. coli
	PDRG1, also known as C2orf126, belongs to the prefoldin subunit beta family. It is predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs. PDRG1 may play a role in chapero...
TMPY-02150	GADD45A Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	GADD45A is a member of the GADD45 Family, and has been found to associate with several cytoplasmic and nuclear factors and has been implicated in several cellular functions, including MAPK signaling, cell cycle regulatio...
TMPJ-00907	GADD45A Protein, Human, Recombinant (His)	Human	E. coli
	Growth Arrest and DNA Damage-Inducible Protein GADD45 α (GADD45A) is a member of the GADD45 family. GADD45A can be induced by UV irradiation, X-rays, growth arrest and alkylating agents, of which can be mediated by some ...
TMPJ-00711	GADD45G Protein, Human, Recombinant (His)	Human	E. coli
	Growth Arrest and DNA Damage-Inducible Protein GADD45 Υ (GADD45G) is a nuclear protein which belongs to the GADD45 family. GADD45G is highly expressed in placenta. GADD45G interacts with various proteins whose transcript...
TMPY-03655	GADD45G Protein, Human, Recombinant	Human	E. coli
	GADD45G, also known as CR6, is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G re...
TMPJ-00700	GADD45B Protein, Human, Recombinant (His)	Human	E. coli
	Growth Arrest and DNA Damage-Inducible Protein GADD45 β (GADD45B) is a member of the GADD45 family. GADD45B has been shown to interact with MAP3K4, ASK1, MAP2K7, and GADD45GIP1. GADD45B is involved in the regulation of g...
TMPY-02953	TEM8/ANTXR1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are ser...
TMPY-02521	HIST3H2A Protein, Human, Recombinant	Human	E. coli
	Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ...
TMPH-01091	CHD1L Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catal...
TMPH-00605	CDTB Protein, E. coli, Recombinant (His & Myc & SUMO)	E. coli	E. coli
	Part of the tripartite complex that is required for the CDT activity. CdtB exhibits a DNA-nicking endonuclease activity, and very probably causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arres...
TMPY-04267	MSH2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and bind...
TMPY-02527	P53R2 Protein, Human, Recombinant (His)	Human	E. coli
	Ribonucleoside reductase subunit M2B, also known as RRM2B or p53R2, is an enzyme belonging to the iron-dependent ribonucleotide reductase (RNR) enzyme family which is essential for DNA synthesis. Ribonucleotide reductase...
TMPH-01350	FOxM1 Protein, Human, Recombinant (GST)	Human	E. coli
	Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in t...
TMPH-00732	RtcB Protein, E. coli, Recombinant (His)	E. coli	P. pastoris (Yeast)
	GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Also acts as a DNA ligase in case of DNA damage by splici...
TMPH-01351	FOxM1 Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in t...
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair protein...
TMPJ-00457	OGG1 Protein, Human, Recombinant	Human	E. coli
	Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamido...
TMPH-03614	DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO)	Synechococcus	E. coli
	Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the ...
TMPH-01008	PNKP Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini ...
TMPH-02997	Dps Protein, Mycobacterium smegmatis, Recombinant (His & SUMO)	Mycobacterium smegmatis	E. coli
	Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical produ...
TMPH-02681	GPX7 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. G...
TMPH-02993	DisA Protein, Mycobacterium paratuberculosis, Recombinant (His & Myc)	Mycobacterium paratuberculosis	E. coli
	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules int...
TMPH-00646	LexA repressor Protein, E. coli, Recombinant (His & SUMO)	E. coli	E. coli
	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA int...
TMPJ-00870	NCK1 Protein, Human, Recombinant (His)	Human	E. coli
	Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, ...
TMPH-02875	ROMO1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.; Induces production of reactive oxygen species (ROS) which are n...
TMPH-03452	NDPK Protein, S. cerevisiae, Recombinant (His)	Saccharomyces cerevisiae	P. pastoris (Yeast)
	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Require...
TMPH-01239	XPC Protein, Human, Recombinant (His)	Human	E. coli
	Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B an...
TMPH-02649	FAN1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficien...
TMPJ-00033	UBE2B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2...
TMPH-01214	DNASE1L3 Protein, Human, Recombinant	Human	E. coli
	Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA...
TMPH-01212	DNASE1L3 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA...
TMPH-01213	DNASE1L3 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA...
TMPJ-01131	UBE2V2 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It forms a heterodimer with UBE2N....
TMPH-03451	NDPK Protein, S. cerevisiae, Recombinant (E. coli, His)	Saccharomyces cerevisiae	E. coli
	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Require...
TMPH-01273	TRIP12 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein a...
TMPY-02421	PARP3 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular resp...
TMPY-02228	P53 Protein, Cynomolgus, Recombinant	Cynomolgus	E. coli
	p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and...
TMPY-00648	UNC5A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	The netrin-1 receptor Uncoordinated Phenotype-5A, or UNC5A, plays an important role in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer. Moreover, UNC5A is cu...
TMPY-00999	UNC5A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The netrin-1 receptor Uncoordinated Phenotype-5A, or UNC5A, plays an important role in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer. Moreover, UNC5A is cu...
TMPY-02495	P19 INK4d Protein, Human, Recombinant (GST)	Human	E. coli
	Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S tran...
TMPJ-00661	PDCD5 Protein, Human, Recombinant (His)	Human	E. coli
	Programmed Cell Death Protein 5 (PDCD5) is a member of the PDCD5 family. PDCD5 is expressed in tumor cells during apoptosis, independent of apoptosis-inducing stimuli. This protein may function in the process of apoptosi...
TMPH-00794	Dps Protein, Helicobacter pylori, Recombinant (His & SUMO)	Helicobacter pylori	E. coli
	Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical produ...
TMPH-01694	MLKL Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localizat...
TMPY-04550	JNK2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environm...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His)	Human	Baculovirus Insect Cells
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections,...
TMPH-02314	XRCC5 Protein, Human, Recombinant (His & MBP)	Human	Baculovirus Insect Cells
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPH-01621	BRCC3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes...
TMPJ-01100	UBE2V1 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inact...
TMPH-02315	XRCC5 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPY-04547	PBK/TOPK Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the chara...
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PDRG1 Protein, Human, Recombinant (His)

TMPY-03601

Species: Human

Expression System: E. coli

GADD45A Protein, Human, Recombinant (His & GST)

TMPY-02150

Species: Human

Expression System: Baculovirus Insect Cells

GADD45A Protein, Human, Recombinant (His)

TMPJ-00907

Species: Human

Expression System: E. coli

GADD45G Protein, Human, Recombinant (His)

TMPJ-00711

Species: Human

Expression System: E. coli

GADD45G Protein, Human, Recombinant

TMPY-03655

Species: Human

Expression System: E. coli

GADD45B Protein, Human, Recombinant (His)

TMPJ-00700

Species: Human

Expression System: E. coli

TEM8/ANTXR1 Protein, Human, Recombinant (hFc)

TMPY-02953

Species: Human

Expression System: HEK293 Cells

HIST3H2A Protein, Human, Recombinant

TMPY-02521

Species: Human

Expression System: E. coli

CHD1L Protein, Human, Recombinant (His & SUMO)

TMPH-01091

Species: Human

Expression System: E. coli

CDTB Protein, E. coli, Recombinant (His & Myc & SUMO)

TMPH-00605

Species: E. coli

Expression System: E. coli

MSH2 Protein, Human, Recombinant (His & GST)

TMPY-04267

Species: Human

Expression System: Baculovirus Insect Cells

p53R2 Protein, Human, Recombinant (His)

TMPY-02527

Species: Human

Expression System: E. coli

FOxM1 Protein, Human, Recombinant (GST)

TMPH-01350

Species: Human

Expression System: E. coli

RtcB Protein, E. coli, Recombinant (His)

TMPH-00732

Species: E. coli

Expression System: P. pastoris (Yeast)

FOxM1 Protein, Human, Recombinant (His & Myc & SUMO)

TMPH-01351

Species: Human

Expression System: E. coli

RNF13 Protein, Human, Recombinant (His & Myc)

TMPH-01267

Species: Human

Expression System: E. coli

OGG1 Protein, Human, Recombinant

TMPJ-00457

Species: Human

Expression System: E. coli

DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO)

TMPH-03614

Species: Synechococcus

Expression System: E. coli

PNKP Protein, Human, Recombinant (His & SUMO)

TMPH-01008

Species: Human

Expression System: E. coli

Dps Protein, Mycobacterium smegmatis, Recombinant (His & SUMO)

TMPH-02997

Species: Mycobacterium smegmatis

Expression System: E. coli

GPX7 Protein, Mouse, Recombinant (His & Myc)

TMPH-02681

Species: Mouse

Expression System: E. coli

DisA Protein, Mycobacterium paratuberculosis, Recombinant (His & Myc)

TMPH-02993

Species: Mycobacterium paratuberculosis

Expression System: E. coli

LexA repressor Protein, E. coli, Recombinant (His & SUMO)

TMPH-00646

Species: E. coli

Expression System: E. coli

NCK1 Protein, Human, Recombinant (His)

TMPJ-00870

Species: Human

Expression System: E. coli

ROMO1 Protein, Mouse, Recombinant (His)

TMPH-02875

Species: Mouse

Expression System: E. coli

NDPK Protein, S. cerevisiae, Recombinant (His)

TMPH-03452

Species: Saccharomyces cerevisiae

Expression System: P. pastoris (Yeast)

XPC Protein, Human, Recombinant (His)

TMPH-01239

Species: Human

Expression System: E. coli

FAN1 Protein, Mouse, Recombinant (His & Myc)

TMPH-02649

Species: Mouse

Expression System: E. coli

UBE2B Protein, Human, Recombinant (His)

TMPJ-00033

Species: Human

Expression System: HEK293 Cells

DNASE1L3 Protein, Human, Recombinant

TMPH-01214

Species: Human

Expression System: E. coli

DNASE1L3 Protein, Human, Recombinant (His & Myc)

TMPH-01212

Species: Human

Expression System: E. coli

DNASE1L3 Protein, Human, Recombinant (His)

TMPH-01213

Species: Human

Expression System: Baculovirus Insect Cells

UBE2V2 Protein, Human, Recombinant (His)

TMPJ-01131

Species: Human

Expression System: E. coli

NDPK Protein, S. cerevisiae, Recombinant (E. coli, His)

TMPH-03451

Species: Saccharomyces cerevisiae

Expression System: E. coli

TRIP12 Protein, Human, Recombinant (His & Myc)

TMPH-01273

Species: Human

Expression System: E. coli

PARP3 Protein, Human, Recombinant (His & GST)

TMPY-02421

Species: Human

Expression System: Baculovirus Insect Cells

p53 Protein, Cynomolgus, Recombinant

TMPY-02228

Species: Cynomolgus

Expression System: E. coli

UNC5A Protein, Human, Recombinant (hFc)

TMPY-00648

Species: Human

Expression System: HEK293 Cells

UNC5A Protein, Human, Recombinant (His)

TMPY-00999

Species: Human

Expression System: HEK293 Cells

p19 INK4d Protein, Human, Recombinant (GST)

TMPY-02495

Species: Human

Expression System: E. coli

PDCD5 Protein, Human, Recombinant (His)

TMPJ-00661

Species: Human

Expression System: E. coli

Dps Protein, Helicobacter pylori, Recombinant (His & SUMO)

TMPH-00794

Species: Helicobacter pylori

Expression System: E. coli

MLKL Protein, Human, Recombinant (E. coli, His)

TMPH-01694

Species: Human

Expression System: E. coli

JNK2 Protein, Human, Recombinant (His)

TMPY-04550

Species: Human

Expression System: Baculovirus Insect Cells

IRF1 Protein, Human, Recombinant (GST & His)

TMPH-01552

Species: Human

Expression System: Baculovirus Insect Cells

XRCC5 Protein, Human, Recombinant (His & MBP)

TMPH-02314

Species: Human

Expression System: Baculovirus Insect Cells

BRCC3 Protein, Human, Recombinant (His & SUMO)

TMPH-01621

Species: Human

Expression System: E. coli

UBE2V1 Protein, Human, Recombinant (His)

TMPJ-01100

Species: Human

Expression System: E. coli

XRCC5 Protein, Human, Recombinant (His & Myc)

TMPH-02315

Species: Human

Expression System: E. coli

PBK/TOPK Protein, Human, Recombinant (His)

TMPY-04547

Species: Human

Expression System: Baculovirus Insect Cells

--------- More ---------

カタログ番号	製品名
L3900	DNA Damage & Repair Compound Library	910 compounds
	A unique collection of 910 DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
L3980	DNA Damage and Repair Compound Library Plus	667 compounds
	Well-chosen 667 compounds with unique structures targeting DNA damage & repair;
L2910	Antioxidant Compound Library	1314 compounds
	Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species (ROS) and a biological system's ability to readily detoxify the reactive intermediates or repair the resulting damage. ...
L3500	Histone Modification Compound Library	469 compounds
	A unique collection of 469 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);
L8600	Ubiquitination Compound Library	210 compounds
	A unique collection of 210 ubiquitination related small chemicals can be used for high throughput and high content screening；

ライブラリー

DNA Damage & Repair Compound Library

L3900

Compounds: 910

DNA Damage and Repair Compound Library Plus

L3980

Compounds: 667

Antioxidant Compound Library

L2910

Compounds: 1314

Histone Modification Compound Library

L3500

Compounds: 469

Ubiquitination Compound Library

L8600

Compounds: 210